Late-onset Parkinsonism in NFjB/c-Rel-deficient mice
نویسندگان
چکیده
1 Department of Biomedical Sciences and Biotechnologies, University of Brescia and National Institute of Neuroscience, 25123 Brescia, Italy 2 National Research Council, Institute of Neuroscience, 09124 Cagliari, Italy 3 Department of Biomedical Science and National Institute of Neuroscience, University of Cagliari, 09124 Cagliari, Italy 4 Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, 37134 Verona, Italy 5 Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK 6 Department of Immunology, Weill Medical College of Cornell University, New York, 10065 NY, USA 7 IRCCS San Camillo Hospital, Venice, Italy
منابع مشابه
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice
Activation of the nuclear factor κB/c-Rel can increase neuronal resilience to pathological noxae by regulating the expression of pro-survival manganese superoxide dismutase (MnSOD, now known as SOD2) and Bcl-xL genes. We show here that c-Rel-deficient (c-rel(-/-)) mice developed a Parkinson's disease-like neuropathology with ageing. At 18 months of age, c-rel(-/-) mice exhibited a significant l...
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تاریخ انتشار 2012